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Notably, tirzepatide (Zepbound) was not approved for weight management in patients with overweight or obesity until shortly before the patient-identification window closed, resulting in most patients in the tirzepatide cohort receiving Mounjaro, which was assumed to be used off-label for chronic weight management in the absence of T2DM

AOD 9604 does not interact with growth hormone receptors, does not affect insulin signaling, and does not cross into the central nervous system to alter appetite or mood

GLP-1 users eating fewer calories are at higher risk for micronutrient deficiencies, particularly B12 , iron, zinc, magnesium, and vitamin D

It analyzes pathway-level variants in SOD2, GPX1, GSTM1 that shape baseline biology the upstream context that applies across all longevity-protocol compounds

While large-scale human trials remain limited, the existing research paints a promising picture

Cancer 20 (1), 28