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Beyond its energy role, NAD+ is the essential substrate of sirtuins (SIRT1-SIRT7), deacetylases that regulate mitochondrial biogenesis, DNA repair, and resistance to cellular stress (Imai & Guarente, Trends Cell Biol 2014)

Normally, NPs biomedical applications require a high hydrophilic character together with the possibility of their conjugation with biological species [18, 28]

Accordingly, a safer and more effective treatment needs to be developed

Understanding these mechanisms helps explain why this peptide has attracted significant research interest for anti-aging applications