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In studies comparing the effect of oral and parenteral cobalamin, large doses (2 to 3 mg) of daily oral B12 appear equally effective to daily parental cobalamin 1 mg in rapidly restoring cobalamin stores and treating the signs of deficiency (215

This vitamin is key for making red blood cells, nerve function, and DNA

Typical assay ranges span 100 nM to 1 M, adjusted per cell type and endpoint measures

It cannot be used as food, dietary supplement or medicine

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As B12 only occurs in animal foods or fortified foods, oral supplementation of B12 and allied B vitamins should be a standard of care for those following a plant based or highly restrictive diet, as well as those over 60 with reduced capability for nutrient absorption