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Even with a healthy diet, it is not always easy to get the right balance of essential nutrients, especially when you are trying to lose weight

Medications know to cause bone marrow suppression (e.g., myelosuppressive antineoplastic agents) may result in a blunted or impeded response to methylcobalamin, vitamin B12 therapy

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That is why you will see both routes described for the same compound, and it is the single most common source of confusion around its dosing

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Because vitamin B12 is water-soluble, your body naturally eliminates any excess, making this a low-risk solution for most people