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The microbial tryptophan metabolite indole acts on the gastrointestinal tract to improve glucose homeostasis in a mouse model of diabetes by enhancing GLP-1 secretion and L cell differentiation

Insulin resistance contributes to poor blood glucose control and diabetes (Wilcox 2005

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Microbiology (1999) 145, 25692576

Hence, the assignment of the glutathione-scaffold site could facilitate the prediction of disulfide substrate preferences of uncharacterized members of the thioredoxin superfamily