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Additionally, high levels of fumarate react with the cysteine group of mitochondrial aconitase-2 and iron-sulfur cluster binding protein-2, facilitating cellular metabolic adaptation to stresses 138

2.15 Real-time quantitative PCR Total RNA was extracted from aortic tissue and endothelial cells using TRIzol reagent (Takara Bio Inc., 9108), following the manufacturers instructions

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So when glutathione levels are low so too is the energy production from each cell in your body

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