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The underlying biochemistry is real

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If the issue lies with absorption, B12 shots or IV infusions are an effective alternative to oral supplements because they are administered via injection or intravenously, meaning they do not need to be absorbed through the digestive process

A study indicates that regular overdose of isolated vitamin B12 supplements, especially among male smokers, may increase the risk of lung cancer (Brasky et al., 2017)

Some patients also experience more positive moods and reduced irritability after vitamin B12 injections

These associations were independent of demographic, socioeconomic, lifestyle factors, use of medications that could have an effect on serum vitamin B12 levels, dietary supplement use and fasting time