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Nat Med 27 , 952953 (2021)
This is intentionally non-prescriptive
Maximum Dosage: If further control is needed after at least 4 weeks on 1 mg, increase to 2 mg once weekly
Skipping doses frequently or stopping treatment without talking to your healthcare provider
Address nighttime dry mouth aggressively using humidifiers, moisture products, and nasal breathing techniques
Preclinical studies have demonstrated beneficial effects of proteasome activation in models of heart failure and ischemiareperfusion injury, 69 further supporting ER proteostasis as a therapeutically actionable axis
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