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In preclinical models, its applied to cultured fibroblasts, epithelial tissues, and immune cells to study telomere dynamics, cell-cycle checkpoints, and oxidative-stress defensesall key processes in cellular aging

Activity measurements for each respiratory chain complex in permeabilized cells were performed according to previous research 85,138

doi: 10.1016/j.yexcr.2010.08.011 145 OkaniwaNSasakiMMizushimaTOgasawaraNFunakiYJohTet al

Altered presynaptic vesicle release and cycling during mGluR-dependent LTD

Loss of 5alpha-reductase type 1 accelerates the development of hepatic steatosis but protects against hepatocellular carcinoma in male mice