Abstract Background Immune-mediated inflammatory diseases (IMIDs) are chronic disorders involving multiple organs and driven by shared pathogenic pathways
This cascade does four things relevant to muscle mass: it increases ribosomal protein synthesis, suppresses the muscle-atrophy transcription factors FoxO1 and FoxO3a, promotes satellite cell differentiation into new myofibers, and reduces autophagy-driven protein degradation
The A Study of Tirzepatide on the Reduction on Morbidity and Mortality in Adults with Obesity (SURMOUNT-MMO) trial assesses tirzepatide's impact on mortality and cardiovascular events in overweight or obese individuals
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Weighing Maternal Health Benefits Against Theoretical Risk Untreated obesity during the postpartum period increases maternal risks for type 2 diabetes, cardiovascular disease, and depressionconditions that directly affect breastfeeding success, mood stability, and overall infant care capacity
doi: 10.1007/s00125-014-3299-4 Summary Keywords alpha-cell, beta-cell, paracrine signaling, GLP-1, glucagon, insulin Citation Holter MM, Saikia M and Cummings BP (2022) Alpha-cell paracrine signaling in the regulation of beta-cell insulin secretion