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Zhai S, Hu X, Hu Y, Wu B, Xing D
All considered, these data strongly suggest that SAMe depletion contributes to multiple pathophysiological processes observed in the AD brain, including the unsilencing of genes involved in AD development and progression, the depletion of acetylcholine, and the inability to appropriately dephosphorylate tau
The enhanced MLM synthesis upon glutamate addition may be attributed to the following mechanisms: (i) glutamate promotes fatty acid biosynthesis (Hung et al
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Discarding the upper plasma, wash with three times volume of PBS for 3 times (re-suspend blood cell with PBS, centrifuge at 600 g for 10 minutes), add equal volume of Reagent I