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After propensity score matching against multiple antidiabetic drug classes (insulin, metformin, SGLT-2 inhibitors, DPP-4 inhibitors, sulfonylureas), results showed: No significant increase in thyroid cancer incidence Median follow-up of ~4.5 years Risk estimates comparable or lower than other glucose-lowering therapies Overall, current epidemiological evidence does not support a clinically meaningful increase in thyroid cancer risk in humans
& Yoon, J
Your dose may need to go up as your prescriber titrates you, but your price won't increaseyou pay the same flat monthly rate regardless of injection strength
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Key Takeaways Prescribers and pharmacies will submit prior authorization requests and claims to a CMS contractor, not Part D plans or their PBMs Detailed conditions for beneficiary eligibility specified Patients will have a copay of $50, but pharmacy reimbursement details remain to be specified Background on the BALANCE Model CMS announced the BALANCE Model in December of last year, in which CMS will negotiate directly with manufacturers on behalf of Part D plan sponsors and state Medicaid agencies for more favorable costs and terms for GLP-1 medications
Weight loss results: Key findings: At the highest dose (12 mg), participants lost an average of 24.2% of body weight Weight loss had not plateaued at 48 weeksparticipants were still losing 72% of participants with prediabetes reverted to normal blood sugar Improvements in blood pressure, lipids, and other metabolic markers Context: These results exceed those seen with semaglutide (~15-17% in trials) and are comparable to or slightly better than tirzepatide (~21% at highest doses)
