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Experiments by Fox et al.(2021) confirmed that LPS treatment significantly increased androstenedione (a testosterone precursor) secretion in rat theca interstitial cells (TICs), accompanied by upregulation of key androgen biosynthesis genes including cytochrome P450 family 17 subfamily A member 1 (rat gene Cyp17a1) and cytochrome P450 family 11 subfamily A member 1 (rat gene Cyp11a1) (48)