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Ligandin, the glutathione S-transferases, and chemically induced hepatocarcinogenesis: a review

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317 In addition, a KD may upregulate potassium channels that are sensitive to ATP opening, reducing the electrical excitability of the brain and increasing the seizure threshold

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The cells treated with Sp showed slight enhancement in levels of GSH (~1.2 fold), together with minor alterations in GSSG levels, compared to untreated samples which exhibited higher GSSG content, thus indicating efficient recycling of GSSG to GSH (Fig