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The Biological Connection to Hair Pigment Hair color is determined by a pigment called melanin, which is produced by specialized cells known as melanocytes

These binding proteins normally inhibit the biological actions of IGFs therefore IG-1 LR3 has been shown to have increased efficacy and function

Thus, the transition from crystal deposition to acute inflammation can be conceptualized as a two-hit process: First hit: MSU crystal deposition on cartilage surfaces activates synovial fibroblasts to release CCL2/MCP-1, recruiting monocytes and establishing subclinical inflammation

Exp Neurol 172:332341

doi: 10.1038/cdd.2015.158 41 GaoMMonianPPanQZhangWXiangJJiangX