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47 Because of the high prevalence of frailty and sarcopenic obesity in the HFpEF population, future studies are required to estimate the proportion of lean body mass loss versus fat loss on GLP-1 RA therapy to identify predictors of the disproportionate loss of muscle mass

External review approval rates for GLP-1 medications are approximately 58% per National Association of Insurance Commissioners data from 2024

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They produce modest body composition shifts, typically reduced visceral fat and improved muscle tone over months, not dramatic weight loss

For systemic research, it must be administered via subcutaneous or intramuscular injection to bypass the digestive tract and ensure bioavailability

Semaglutide may be in the form of a salt, preferably a pharmaceutically acceptable salt