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Butyrate-modified drug delivery: enhancing bioavailability and targeted therapy via transporter exploitation Monocarboxylate transporters in butyrate absorption and targeted drug delivery systems In the intestinal lumen, butyrate mainly exists in an ionized form and necessitates specialized transmembrane transporters for cellular uptake [1, 76]

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Subcutaneous injection bypasses all of these barriers except plasma half-life, which for unmodified small peptides is generally very short (minutes to low hours, based on class-level pharmacokinetic data for similar unmodified peptides)

SpegelPSharoykoVVGoehringIDanielssonAPMalmgrenSNagornyCLet al

BPC-157 Injection vs Oral Peptide: The Core Pharmacokinetic Difference The central question in the BPC-157 injection vs oral peptide debate is bioavailability the fraction of the administered dose that reaches systemic circulation intact and at therapeutically relevant concentrations