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Whether glucagon counter-regulation to hypoglycemia is affected during DPP-4 inhibition in type 2 diabetes has been studied in drug-nave subjects (138), in subjects when a DPP-4 inhibition was added on to insulin therapy (139), and in elderly subjects with metformin-treated type 2 diabetes (140)
To improve methylation, increasing foods high in folate, B12, and B6 are important nutrients to get daily
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Ishibashi Y, Matsui T, Takeuchi M, Yamagishi S: Glucagon-like peptide-1 (GLP-1) inhibits advanced glycation end product (AGE)-induced up-regulation of VCAM-1 mRNA levels in endothelial cells by suppressing AGE receptor (RAGE) expression
On the other hand, exclusion criteria included (1) review articles with poor experimental data, (2) research studies without clear methodologies, (3) research articles unrelated to pharmaceutical prospect of antioxidants and (4) publications without scope of our research work, (5) non-peer-reviewed studies, (6) literature older than 25 years, as well as (6) unpublished work
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