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The TMCM was kept at 37 C in 5% CO 2 and passaged with the trypsin-EDTA method

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A reduction in CYPOR protein levels prevented NFT-dependent accumulation of Nrf2 protein and partially attenuated the NFT-dependent increase in glutathione levels

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GSH AS MAIN REGULATOR OF CELLULAR REDOX STATUS AND REDOX SIGNAL TRANSDUCTION The glutathione redox couple GSH/GSSG has a great importance in the cells and together with other redox-active couples, including NADPH/NADP + , Trx-SH/Trx-SS regulates and maintains the appropriate cellular redox status