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The authors found the glucose infusion rate (GIR) during the clamp study decreased with OXM compared with OXMQ3E in wild-type mice, likely due to increased hepatic glucose output from GCGR agonism with OXM

While initial payer response to this new crop of obesity treatments was lukewarm, in March 2024, Wegovy became the first weight-loss drug approved for lowering the risk of cardiovascular disease complications, like heart attack and stroke, in overweight adults

Evidence from clinical trials and real-world data suggests these medications can be used safely in many older people, but certain precautions are essential

Current serotonin medications are aimed at increasing central 5-HT neurotransmission in the brain, and there are no approved indications for manipulating peripheral 5-HT, though peripheral 5-HT synthesis is being considered as a potential target for developing pharmacological agents in some disorders (8, 9)

Whereas in Germany, the market access differs from the systems followed in many other countries as no pricing and reimbursement approval is required during launch of a new therapy

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