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A 2025 study found irregular menstrual cycles dropped from 86% to 32% on tirzepatide, with significant improvement in insulin resistance.[10] A real-world study presented at ObesityWeek 2025 found over 90% of PCOS patients on tirzepatide hit at least 10% weight loss within 10 months.[11] Theres even a registered clinical trial specifically testing tirzepatide for PCOS

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Euglycaemic DKA (where blood glucose may not be extremely elevated) can occur, particularly during illness, surgery, or significant dietary restriction

If you have type 2 diabetes, it is recommended that you lose your excess weight