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However, severe persistent vomiting (more than 3 episodes per day for more than 2 days), signs of pancreatitis (severe abdominal pain radiating to the back), or allergic reactions (hives, difficulty breathing, facial swelling) warrant immediate protocol cessation and medical attention

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Patients should inform their healthcare provider about all skincare products being used

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Given the central role of mitochondria, the comprehensive connection between HIF, mitochondrial activity, and chemoresistance provides a new direction of research for explaining therapy failure and proposing innovative treatment strategies [116]