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The GIP component improves insulin sensitivity and enhances fat metabolism, while the GLP-1 component provides superior hunger suppression

Archiv Psychiatr Nervenkrankheit 1944;117:76-136

FDA between December 2017 and December 2024

Based on these initial studies and comprehensive characterization, liraglutide was selected as having the best properties, combining high receptor potency with pharmacokinetics (PK) that are optimum for OD dosing ( Following the selection of liraglutide as the first GLP-1-based analog suitable for OD dosing, further analysis of its structural activity was published ( The Discovery of Semaglutide Successful clinical trials with exenatide and liraglutide led to an increased interest in GLP-1-based therapies

The challenge here is accessibility