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Inclusion criteria This review considered peer-reviewed studies of L-carnitine supplementation in subjects with coronary artery disease across predefined designs, each with a distinct role, including preclinical evidence such as animal studies which provided mechanistic evidence and insights on emerging pathways, as well as clinical evidence such as case reports, cross-sectional studies, observational studies, retrospective analyses, randomized controlled trials, systematic review and meta-analyses which provided primary evidence as well as quantitative analysis of clinical endpoints
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Moreover, L-carnitine mitigates post-ischemic myocardial injury primarily by counteracting the toxic impact of increased free fatty acid concentration and promoting more efficient carbohydrates metabolism (Ferrari et al
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