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In the absence of safety data, most clinicians advise that pregnant or breastfeeding individuals avoid this compounded preparation unless the anticipated benefit clearly outweighs theoretical fetal or neonatal risks

Inhibition of microRNA-92a ameliorates lipopolysaccharide-induced endothelial barrier dysfunction by targeting ITGA5 through the PI3K/Akt signaling pathway in human pulmonary microvascular endothelial cells

Seizure disorders: Compounds affecting neuroplasticity and excitability theoretically warrant caution in seizure-prone individuals

All cited studies involve preclinical or in vitro models

However, it also have potential side effects which must be considered

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