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While semaglutide primarily works by targeting GLP-1 receptors in the pancreas and digestive system, these receptors are also found in the brain

It's not positioned as a cure, but rather as a supportive element in a broader gut health strategy that includes whole foods, hydration, and mindfulness around inflammation triggers

Notably, when RNF4 was incubated with the CCW16-based PROTAC 2a , we also observed the formation of a covalent bond between 2a and RNF4 at cysteine C91 ( Figure 3D (pink), Supplementary Figure 3C )

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Digoxin, used for heart failure and arrhythmias, is another narrow therapeutic window drug