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Severe / Rare Adverse Events (Shared Risks with Boxed Warnings) The following risks apply to both medications equally: Risk of thyroid C-cell tumors: Contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia type 2 (MEN2)

Zhao N, Liu CC, Van Ingelgom AJ, Martens YA, Linares C, Knight JA, et al

Removal of bile duct stones by ERCP with papillotomy is best if undertaken within 24 h of the patients admission and the value of this approach remains in terms of morbidity and mortality in patients with acute biliary pancreatitis and concomitant cholangitis [209, 210]

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Optional: If the lysate is too viscous, add RNase A (10 g/mL) and DNase I (5 g/mL) and incubate on ice for 10-15 minutes