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If the ratio falls too low, the highly oxidized environment triggers cell cycle arrest or programmed cell death (apoptosis), leading to widespread tissue damage and profound fatigue

doi: 10.1073/pnas.94.4.1500 84 HsiehG

O-GlcNAc modification of Sp1 mediates hyperglycaemia-induced ICAM-1 up-regulation in endothelial cells

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