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However, new insight indicates that a combination of low-dosed BAL plus DMPS could be a preferred antidotal therapy to obtain mobilization of the intracerebral deposits into the circulation for subsequent rapid urinary excretion

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AOD-9604, despite a safety database spanning six trials and around 900 participants, saw its early positive efficacy signal fail to replicate in its largest confirmatory trial meaning its safety data is well established

To overcome the problem, prodrugs activated only after oral absorption were developed

Phase II study of sorafenib in patients with metastatic or recurrent sarcomas

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