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Many people experience increased hunger, mood changes, and metabolic shifts when discontinuing treatment

Cell Stress Chaperones 23 , 189194 (2018)

Also seek prompt medical attention for: Severe, persistent abdominal pain (which may indicate pancreatitis) Yellowing of skin/eyes or right upper abdominal pain (possible gallbladder disease) Symptoms of dehydration (dizziness, dry mouth, decreased urination) Any neck lump or hoarseness (relevant to thyroid tumor risk warning) Schedule a routine appointment to discuss: Pre-existing cardiovascular conditions including coronary artery disease, heart failure, arrhythmias, or valvular heart disease should be disclosed before starting tirzepatide

Key difference: Side effect rates are roughly comparable between semaglutide and tirzepatide in clinical trials

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