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Bydureon kept exenatide relevant as newer GLP-1 drugs emerged, but eventually exenatides role diminished since newer agents offered even greater efficacy

With TZP treatment, insulin sensitivity rises by 65.7%, measured by the glucose infusion rate indispensable to maintain euglycemia, and the rise was 20.5% greater with TZP than with semaglutide 37.5% with semaglutide 1 mg)

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Thus, further studies are needed to better elucidate the effects of different GLP-1R agonists on anti-inflammatory actions in depression

These effects are linked to its ability to normalize nitric oxide production, regulate oxidative balance, and maintain microvascular integrity across multiple tissues

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