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With insulin, there is risk of weight gain, for hypoglycemia, and theres more treatment burden and need for glucose monitoring. GLP-1 drugs have also been shown to have cardiovascular benefits, she adds, though further clinical trials are needed to assess orforgliprons effects on heart health

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This high demand is behind nationwide shortages that have been happening since 2022 and are expected to last throughout 2024

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A sugar ester and an iridoid glycoside from Scrophularia ningpoensis