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This is also the structure Novo Nordisk's own investigational semaglutide+cagrilintide combination used in REDEFINE 1 (Garvey et al., NEJM 2025) both components stepped in parallel through a 16-week ramp rather than introduced together at maintenance

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MOTS-c is usually dosed in the morning on training days, ideally 30-60 minutes before exercise - that lines up with the peptide's natural exercise-induced expression pattern and is supported by animal-study timing data