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Niacinamide at the doses present in compounded tirzepatide (approximately 1 to 2 mg per injection) is generally well tolerated

Studies have shown that this antioxidant activity can improve skin brightness (by reducing melanin), increase skin moisture, improve skin elasticity and minimize the appearance of wrinkles, resulting in a more youthful skin, all without significant side effects

Caution is advised when glutathione is administered concurrently with these medications, as it may alter their metabolism or pharmacodynamics