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Exp Mol Med 55:16521658

Horses were given the following three treatment diets: control (without supplementation), MSM 8 mg/kg, and combined supplements (MSM 8 mg/kg + Vit-C 5 mg/kg)

It results from a localized accumulation of melanin in the basal epithelial cells, without an increase in the number of melanocytes themselves

Mycol Prog 24:116

A medication compounded under 503A regulations receives substantially less federal scrutiny than one produced by a 503B facility, which in turn receives less scrutiny than an FDA-approved pharmaceutical product