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However, these results must be contextualised carefully: Phase 2 trials are not powered to detect cardiovascular outcomes such as myocardial infarction, stroke, or cardiovascular mortality No dedicated cardiovascular outcome trial (CVOT) data exist for retatrutide such trials are required before definitive conclusions about cardiovascular benefit or risk can be drawn

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This strategy maximizes the proportion of patients who feel and sustain benefits

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This kind of optionality may provide incremental long-term strategic value if the regulatory landscape surrounding psychedelic-based therapies continues to evolve

the question is which fits your lifestyle and comfort level