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Older patients and those experiencing hormonal transitions may need longer treatment courses or ongoing maintenance therapy because their underlying metabolic environment is less forgiving of medication withdrawal

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In the meantime, the regulator has agreed to not take action against compounders of tirzepatide until December 19, unless the agency makes an earlier decision on remand, according to a Leerink investor note issued last month

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Long-term use is associated with more serious effects, including osteoporosis, adrenal suppression, and increased susceptibility to infections

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