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doi: 10.1016/S0140-6736(18)32260-8 112 FrasJPDaviesMJRosenstockJPrez ManghiFCFernndez LandLBergmanBKet al

The AWARD trial series demonstrated A1C reductions between 0.7% and 1.6% depending on dosage and patient background

Unlike E3 and E4 mice, in E2 mice plasma acylcarnitines, particularly LCAs, remained elevated with age and overall higher than in other genotypes regardless of age

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A genome-wide methylation analysis revealed that high IMF levels were highly correlated with the hypermethylation of the promoters of three genes: ATP binding cassette subfamily A member 1 ( ABCA1 ), COL6A1 , and glutathione S-transferase theta 1-like ( GSTT1L )