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If persistent fatigue occurs, it warrants medical review to exclude other causes such as anaemia, thyroid dysfunction, or inadequate diabetes control

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In a phase 1, 6-week randomized controlled trial (RCT) that included scores on the Food Craving Questionnaire-State, the Food Craving Inventory, the Eating Inventory, the Power of Food Scale, and an appetite Visual Analogue Scale as secondary outcomes, tirzepatide was associated with reductions in appetite, hunger, cravings, tendency to overeat, and reactivity to environmental food cues, versus placebo [9]

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Taking one week at maintenance every eight to ten weeks may actually accelerate long-term progress

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