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The coupling of the remaining amino acids on the side chain was completed at one time with the PEG-PEG--Glu-Octadecanedioic Acid mono-tert-butyl ester fragment, and 223 g peptide resin was obtained after coupling completed
To overcome the rapid degradation of GLP-1, two approaches have been developed: 1) GLP-1 receptor agonists resistant to DPP-IV metabolism, and 2) DPP-IV inhibitors to augment the effect of native/endogenous GLP-1
PubMed Central Sturm, R
G.SantraT
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