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Emphasis is placed on secretion and action of GIP, GLP-1, and GLP-2 as part of the gut-bone axis

While timing alone is unlikely to be the sole cause, it is one piece of the optimization puzzle that is easy to adjust and test

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Long-term use without medical supervision might lead to hormonal imbalances and issues like joint pain or altered glucose metabolism

It is linked to a condition called NAION, which damages the optic nerve and can be irreversible