Mutations in the gene encoding OCTN2, SLC22A5 , can impair fatty acid metabolism and lead to systemic primary carnitine deficiency (SPCD, OMIM 212140) 8 , an autosomal recessive disorder whose clinical manifestations include cardiomyopathy, hypoglycemia, chronic muscle weakness and liver dysfunction 9
However, limitations included the restricted inclusion criteria (eGFR range of 2075 mL/min/1.73 m 2 and albuminuria requirements), which limit generalizability to patients with higher or lower eGFR or preserved eGFR without albuminuria
Novo Nordisk officials said the price cut is the latest in a series of moves the Danish drugmaker has pursued to make the drugs more affordable for U.S
Final practical takeaways 1 Confirm the medical reason for injections with labs
Patients should remember that any medication choice must align with their medical history
That knowledge helps them stay consistent with both treatment and lifestyle