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2025 Wegovy Study Shows Increase in NAION Risk for Diabetes Patients A 2025 study in JAMA Ophthalmology investigated the risk of NAION in people with Type 2 diabetes using semaglutide (Wegovy)
Semaglutide is a compounded GLP-1 medication and the active ingredient in Rybelsus, Ozempic and Wegovy
It is strongly linked to increased risk of cardiovascular disease, type 2 diabetes, and metabolic syndrome
While different questions used different semantics, the drops were consistent: from 53 percent to 15 percent for those who had uncontrollable food thoughts, from 60 percent to 20 percent for those whose food thoughts had negative effects, and from 47 percent to 15 percent for those whose food thoughts distracted them from everyday life
However, tirzepatide was removed from the FDA drug shortage list, triggering restrictions on compounded versions