By mitigating metabolic stress in these specific auditory structures, SPI-1005 helps preserve low-frequency auditory thresholds and speech discrimination in a subset of patients
Acknowledgements We thank Umut Erhan, Azadeh Houshman-regaard and Anders Strathe of Novo Nordisk A/S (Denmark) and Zu Ning of Novo Nordisk China A/S (China) for their contributions to the manuscript
Otherwise, side effects are about the same
DOI: 10.1056/NEJMoa2416394
This should be balanced against potential negative effects on body composition, bone density and frailty fractures [90, 91]
However, safety assessments of oral semaglutide in the SOUL trial ( 5 Conclusion Semaglutide significantly reduces cardiovascular risk in patients with T2DM, primarily by improving MACE, nonfatal myocardial infarction, and revascularization outcomes, while modestly lowering HF hospitalization risk