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FAERS collects reports from manufacturers, healthcare professionals, and patients, providing a valuable resource for post-marketing pharmacovigilance 14

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Studies have shown that patients taking semaglutide GLP-1 lost more weight than those on a placebo, and had a greater reduction in body fat

However, overexpression of Pfkfb3 activates glycolysis in neurons through the APC/C-Cdh1 pathway, which inhibits the pentose phosphate pathway (PPP), reduces the oxidation of glucose-6-phosphate (G6P), decreases the production of reduced glutathione, and finally leads to oxidative stress and apoptosis (Herrero-Mendez et al., 2009)