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Davis WA, Knuiman MW, Davis TME
(last reviewed 2022) Arthritis
Before taking Topiramate, tell your healthcare provider about all of your medical conditions , including if you: Have or have had depression, mood problems, or suicidal thoughts or behavior Have kidney problems, have kidney stones, or are getting kidney dialysis Have a history of metabolic acidosis (too much acid in the blood) Have liver problems Have weak, brittle, or soft bones (osteomalacia, osteoporosis, osteopenia, or decreased bone density) Have lung or breathing problems Have eye problems, especially glaucoma Have diarrhea Have a growth problem Are on a diet high in fat and low in carbohydrates, which is called a ketogenic diet Are having surgery Are pregnant or plan to become pregnant Are breastfeeding or plan to breastfeed
Proactive education, slow dose increases, lifestyle changes, and early use of supportive treatments can prevent symptoms from becoming severe
Sue YM, Chou HC, Chang CC, Yang NJ, Chou Y, Juan SH (2014) L-carnitine protects against carboplatin-mediated renal injury: AMPK- and PPAR-dependent inactivation of NFAT3
It covers the purpose of GLP in non-clinical studies, the differences between GLP, G(C)LP, and GCP, and the key regulatory references
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