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High supplemental doses may cause nerve damage and skin lesions, but getting vitamin B6 from food doesnt appear to have any negative effects

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However, I would be lying if I said weight isnt a big part of that conversation

10.1016/j.bbrep.2015.11.008 92 KhrapkoK

The receptors are known as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)

15 Diabetes is regarded as an independent risk factor for pill-induced oesophagitis, which occurs due to the delayed transit of medication through the oesophagus as a result of impaired oesophageal motility, leading to prolonged exposure of the oesophagus to the medication