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IGF-1 LR3 is a modified analog of human Insulin-Like Growth Factor-1, engineered with two structural changes an arginine substitution and a 13-amino acid N-terminal extension that reduce its binding to IGF-1 binding proteins
Yao, Y., Xu, X
It is a synthetic tetrapeptide modeled on a pineal-derived molecule and studied for decades by Russian gerontology researcher Vladimir Khavinson for its effect on age-related markers
The circadian clock is entrained by light perceived by phytochromes (red and far-red [FR] light receptors), cryptochromes (blue light receptors), and temperature (Greenham and McClung, 2015)
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Animal studies reveal doxorubicin administration causes dramatic weight loss and liver damage, evidenced by elevated plasma aspartate aminotransferase (AST) levels, an established marker of hepatotoxicity
