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The inhibition of catalase by glutathione

Glutathione (GSH) is the most abundant intracellular thiol and a critical component of the cellular antioxidant defense system

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Many studies have evaluated daily use of ashwagandha for several weeks to months

The clinical trial protocol starts at 0.25 mg to 0.3 mg weekly and increases every 4 weeks through escalation steps of 0.6 mg, 1.2 mg, 1.8 mg, and finally 2.4 mg

The GSH/GSSG ratio usually indicates the level of cellular oxidative stress, which accelerates the conversion of GSH to GSSG and decreases the GSH/GSSG ratio [26]