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Several important patterns emerged from these cases
In receptor assays it preferentially activates the human amylin-1 receptor (AMY1R) over the calcitonin receptor (CTR) and AMY3R a selectivity profile that distinguishes it from non-selective amylin analogs such as cagrilintide
The study further proposed that exendin-4 might bind to GLP-1 receptor, mediated by protein kinase A (PKA), and act on the Wnt/-catenin pathway in osteocytes in order to reduce sclerostin expression and promote bone formation ( There are other possible pathways by which GLP-1 could affect bone formation
![examples of glp 1 analogues List current GLP-1 and its analogs [36-39] List of current GLP-1 and –](https://www.researchgate.net/publication/371322849/figure/tbl1/AS:11431281165596278@1686056417230/List-of-current-GLP-1-and-its-analogs-36-39.png)
